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Rabbit Anti-FGF20/FITC Conjugated antibody
background:
The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009].
Function:
Neurotrophic factor that regulates central nervous development and function.
Subunit:
Homodimer. Interacts with FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
Subcellular Location:
Secreted.
Tissue Specificity:
Predominantly expressed in the cerebellum.
Similarity:
Belongs to the heparin-binding growth factors family.
Database links:
Entrez Gene: 26281 Human
Entrez Gene: 80857 Mouse
Entrez Gene: 66017 Rat
Omim: 605558 Human
SwissProt: Q9NP95 Human
SwissProt: Q9ESL9 Mouse
SwissProt: Q9EST9 Rat
Unigene: 199905 Human
Unigene: 425526 Mouse
Unigene: 64492 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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