Rabbit Anti-DCK/FITC Conjugated antibody

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DCK; dCK; DCK protein; DCK_HUMAN; Deoxycytidine kinase; EC 2.7.1; EC 2.7.1.74; MGC117410; MGC138632; OTTHUMP00000219118; OTTHUMP00000219119.

Cat:

SL5749R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Pig,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human DCK

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

31kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Deoxycytidine kinase is responsible for the phosphorylation of several deoxyribonucleosides and their analogs. Deficiency of this enzyme activity is associated with resistance to antiviral and anticancer chemotherapeutic agents, whereas increased enzyme activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. It is the rate limiting enzyme in the activation of many important anticancer and retroviral drugs and its activity is often decreased in cells that are resistant to cytosine arabinoside.

Function:
Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.

Subunit:
Homodimer.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1.

Similarity:
Belongs to the DCK/DGK family.

Database links:

Entrez Gene: 1633 Human

Entrez Gene: 13178 Mouse

Entrez Gene: 79127 Rat

Omim: 125450 Human

SwissProt: Q3MHR2 Cow

SwissProt: P27707 Human

SwissProt: P43346 Mouse

SwissProt: P48769 Rat

Unigene: 709 Human

Unigene: 298892 Mouse

Unigene: 10058 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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