Rabbit Anti-DSF4B/FITC Conjugated antibody

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Activator of S phase kinase like protein 1; ASK like protein 1; ASKL1; chifb; Chiffon homolog B; DBF 4B; DBF4 homolog B (S. cerevisiae); DBF4 homolog B; Dbf4 related factor 1; DRF1; Protein DBF4 homolog B; ZDBF1B; Zinc finger DBF type containing 1B; DBF4B

Cat:

SL5748R-FITC

Species Reactivity：

Human,

Immunogen：

KLH conjugated synthetic peptide derived from human DBF4B/ASKL1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

18kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
DSF4B is a regulatory subunit for CDC7, a serine-threonine kinase which links cell cycle regulation to genome duplication. The complex CDC7-DSF4B selectively phosphorylates the MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle. DSF4B localizes to the nucleus and its expression is cell cycle-regulated.

Function:
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DSF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle.

Subunit:
Forms a complex with CDC7. Note that CDC7 forms distinct complex either with DSF4/DSF4A or DSF4B. Such complexes are stable upon replication stress.

Subcellular Location:
Nucleus. Note=Predominantly found in soluble fraction but not in the chromatin-bound fraction.

Tissue Specificity:
Widely expressed. Highly expressed in testis.

Post-translational modifications:
Phosphorylated.

Similarity:
Contains 1 BRCT domain.
Contains 1 DSF4-type zinc finger.

Database links:

Entrez Gene: 80174 Human

Omim: 611661 Human

SwissProt: Q8NFT6 Human

Unigene: 369998 Human

Unigene: 728986 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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