Rabbit Anti-Cdc23/FITC Conjugated antibody

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ANAPC8; Anaphase promoting complex subunit 8; Anaphase-promoting complex subunit 8; Apc 8; APC8; Cdc 23; CDC23; CDC23_HUMAN; cell division cycle 23; Cell division cycle 23 homolog; Cell division cycle protein 23; Cell division cycle protein 23 homolog; Cu

Cat:

SL5740R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human Cdc23

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

69kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Subunit:
The APC/C is composed of at least 12 subunits.

Post-translational modifications:
Phosphorylated. Phosphorylation on Thr-562 occurs specifically during mitosis.

Similarity:
Belongs to the APC8/CDC23 family.
Contains 9 TPR repeats.

Database links:

Entrez Gene: 8697 Human

Entrez Gene: 52563 Mouse

Entrez Gene: 291689 Rat

Omim: 603462 Human

SwissProt: Q9UJX2 Human

SwissProt: Q8BGZ4 Mouse

Unigene: 73625 Human

Unigene: 196638 Mouse

Unigene: 139314 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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