background:
RAP1GAP, an 85/95kDa protein, is a member of a family of GAPs specific for Rap1. Though to be an important tumor suppressor, Rap1GAP has no sequence homology with other GAPs such as RasGAP, RanGAP and RhoGAP. Purified as a cytosolic and membrane-bound protein, both isoforms consist of two monomers each contain a dimerization and a catalytic domain. Mutations in the GAP domain of the tumor suppressor tuberin, can cause benign tumor phenotype tuberous sclerosis. There are 2 isoforms produced by alternative splicing.
Function:
GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KRESLV1), converting it to the putatively inactive GDP-bound state.
Subunit:
Homodimer and heterodimer with RAP1B.
Subcellular Location:
Golgi apparatus membrane; Peripheral membrane protein.
Tissue Specificity:
Significant expression seen in the brain, kidney and pancreas. Abundant in the cerebral cortex and expressed at much lower levels in the spinal cord. Not detected in the lymphoid tissues.
Similarity:
Contains 1 GoLoco domain.
Contains 1 Rap-GAP domain.
Database links:
Entrez Gene: 5909 Human
Entrez Gene: 110351 Mouse
Entrez Gene: 313644 Rat
Omim: 600278 Human
SwissProt: P47736 Human
SwissProt: A2ALS5 Mouse
Unigene: 148178 Human
Unigene: 36763 Mouse
Unigene: 3636 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
RaplGAP在细胞的粘附连接及形成过程中所发挥着一定作用。RaplGAP是小分子G蛋白Rapl的GTP酶激活蛋白(GTPase activating protein)，它可以加速rap1由活化形式(与GTP结合)转变为去活化形式(与GDP结合)。由于粘附连接的破坏或延迟了粘附连接形成的过程，对肿瘤转移有着密切的联系。
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