Rabbit Anti-CYP2E1/FITC Conjugated antibody

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4-nitrophenol 2-hydroxylase; CP2E1_HUMAN; CPE 1; CPE1; CYP2E; CYP2E1; CYP2E1; CYPIIE1; Cytochrome P450 2E1; cytochrome P450 family 2 subfamily E polypeptide 1; Cytochrome P450 isozyme 3A; Cytochrome P450 LM3A; Cytochrome P450 subfamily IIE (ethanol induci

Cat:

SL4562R-FITC

Species Reactivity：

Human,Rat,(predicted: Mouse,Dog,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human CYP2E1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

57kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and biosynthesis. Cytochrome P450 2E1 is induced by ethanol, diabetes and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, and exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.

Function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.

Subcellular Location:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Similarity:
Belongs to the cytochrome P450 family.

Database links:

Entrez Gene: 1571 Human

Entrez Gene: 13106 Mouse

Entrez Gene: 25086 Rat

Omim: 14840 Human

SwissProt: P05181 Human

SwissProt: Q05421 Mouse

SwissProt: P08682 Rabbit

SwissProt: P05182 Rat

Unigene: 12907 Human

Unigene: 21758 Mouse

Unigene: 1372 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

细胞色素P450 2E1(CYP2E1)可被乙醇等化合物诱导, 参与多种前致癌物(N-亚硝胺、苯胺、氯乙烯、氨基甲酸乙酯)的代谢活化,诱发肿瘤的发生。

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