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Rabbit Anti-TCPTP/PTPIP51/FITC Conjugated antibody
background:
FAM82A2, or family with sequence similarity 82, member C, may participate in differentiation and apoptosis of keratinocytes. Overexpression of FAM82A2 induces apoptosis.
Function:
Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.
Subunit:
Interacts with PTPN2. Interacts with microtubules. Interacts with VAPB.
Subcellular Location:
Mitochondrion membrane; Single-pass membrane protein. Mitochondrion outer membrane. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles.
Tissue Specificity:
Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high expression. In skeletal muscle, its presence is restricted to fibers of the fast twitch type. In surface epithelia containing ciliated cells, it is associated with the microtubular structures responsible for ciliary movement. Also present in specific structures of the central nervous system such as neurons of the hippocampal region, ganglion cells of the autonomic nervous system, and axons of the peripheral nervous system (at protein level). Widely expressed.
Similarity:
Belongs to the RMDN family.
Database links:
Entrez Gene: 5771 Human
Entrez Gene: 19255 Mouse
Entrez Gene: 117063 Rat
Omim: 176887 Human
SwissProt: P17706 Human
SwissProt: Q0636 Mouse
SwissProt: P35233 Rat
Unigene: 654527 Human
Unigene: 663373 Human
Unigene: 260433 Mouse
Unigene: 33497 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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