Rabbit Anti-HOXA5/FITC Conjugated antibody

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Homeo box 1C antibody Homeobox A5 antibody Homeobox protein HOXA5 antibody HOX 1 antibody HOX 1.3 antibody HOX 1C antibody HOX1 antibody HOX1.3 antibody HOX1C antibody; HXA5_HUMAN.

Cat:

SL5713R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human HOXA5

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

29 kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
HOXA5 upregulates both p53 promoter-reporter constructs and endogenous p53 synthesis, leading to apoptosis. HOXA5 is detectable in approximately one-third of primary tumors. Lack of HOXA5 expression strongly correlates with methylation of its promoter region, suggesting a causal role for methylation in the silencing of HOXA5 gene expression. HOXA5 expression is an important step in tumorigenesis and loss of expression of p53 in human breast cancer may be primarily due to lack of expression of HOXA5.

Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the Antp homeobox family.
Contains 1 homeobox DNA-binding domain.

Database links:

Entrez Gene: 642 Human

Entrez Gene: 15402 Mouse

Entrez Gene: 79241 Rat

Omim: 142952 Human

SwissProt: P20719 Human

SwissProt: P09021 Mouse

SwissProt: P52949 Rat

Unigene: 655218 Human

Unigene: 173 Mouse

Unigene: 8465 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

p53基因保护细胞不会癌变，HOXA5协助细胞的p53保持适当水平。如果HOXA5水平下降或完全缺乏，p53基因就不能防止细胞癌变。低水平的HOXA5通过另一种促甲基化机制使基因不能表达而发生。正常状态下，p53肿瘤抑制蛋白发现DNA的损伤，将信息传递给细胞以修复损伤或者导致死亡。过少或没有p53不仅减弱细胞正常功能，而且降低细胞感受损伤的能力。因此，若细胞缺少HOXA5蛋白也很可能是肿瘤发展的重要过程。

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