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Rabbit Anti-Nck beta/FITC Conjugated antibody
background:
This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].
Function:
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.
Subunit:
Interacts with DOCK1, LIMS1 and TGFB1I1. Part of a complex containing PPP1R15B, PP1 and NCK2. Interacts with FASLG (By similarity). Interacts with AXL. Interacts with PAK1, PKN2 and SOS1. Interacts (via SH2 domain) with EGFR. Interacts (via SH2 domain) with DDR1.
Subcellular Location:
Cytoplasm. Endoplasmic reticulum.
Tissue Specificity:
Ubiquitous.
Post-translational modifications:
Phosphorylated.
Similarity:
Contains 1 SH2 domain.
Contains 3 SH3 domains.
Database links:
Entrez Gene: 888 Human
Entrez Gene: 17974 Mouse
Omim: 604930 Human
SwissProt: O43639 Human
SwissProt: O55033 Mouse
Unigene: 529244 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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