background:
Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-III complex is probably involved in the concentration of MVB cargo. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein PCGF4/BMI1 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. In case of infection, the HISLV1 virus takes advantage of the ESCRT-III complex for budding and exocytic cargoes of viral proteins.
Function:
Probable peripherally associated component of theendosomal sorting required for transport complex III (ESCRT-III)which is involved in multivesicular bodies (MVBs) formation andsorting of endosomal cargo proteins into MVBs. MVBs containintraluminal vesicles (ILVs) that are generated by invagination andscission from the limiting membrane of the endosome and mostly aredelivered to lysosomes enabling degradation of membrane proteins,such as stimulated growth factor receptors, lysosomal enzymes andlipids. The MVB pathway appears to require the sequential functionof ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostlydissociate from the invaginating membrane before the ILV isreleased. The ESCRT machinery also functions in topologicallyequivalent membrane fission events, such as the terminal stages ofcytokinesis and the budding of enveloped viruses (HISLV1 and otherlentiviruses). ESCRT-III proteins are believed to mediate thenecessary vesicle extrusion and/or membrane fission activities,possibly in conjunction with the AAA ATPase VPS4. Involved incytokinesis. Involved in recruiting VPS4A and/or VPS4B to themidbody of dividing cells. May also be involved in chromosomecondensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4to regions of condensed chromatin. May play a role in stable cellcycle progression and in PcG gene silencing.
Subunit:
Probable peripherally associated component of theendosomal sorting required for transport complex III (ESCRT-III).ESCRT-III components are thought to multimerize to form a flatlattice on the perimeter membrane of the endosome. Several assemblyforms of ESCRT-III may exist that interact and act sequentally.Self-associates. Interacts with CHMP1B. Interacts with VPS4A.Interacts with VPS4B. Interacts with PHF1. Interacts with IST1.
Subcellular Location:
Cytoplasm. Endosome membrane; Peripheral membrane protein. Nucleus matrix.
Tissue Specificity:
Expressed in placenta, cultured skin fibroblasts and in osteoblast cell line MG63.
Similarity:
Belongs to the SNF7 family.
Database links:
Entrez Gene: 5119 Human
Entrez Gene: 234852 Mouse
Entrez Gene: 365024 Rat
Omim: 112810 Human
SwissProt: Q9HD42 Human
SwissProt: Q921W0 Mouse
Unigene: 589427 Human
Unigene: 41596 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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