Rabbit Anti-hnRNP F/FITC Conjugated antibody

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Heterogeneous nuclear ribonucleoprotein F; Heterogeneous nuclear ribonucleoprotein F; hnRNP F; HNRNPF; hnRP F; hnRPF; mcs94 1; MGC110997; Nucleolin like protein; Nucleolin like protein mcs94 1; OK/SW cl.23; Ribonucleoprotein F; HNRPF_HUMAN.

Cat:

SL4205R-FITC

Species Reactivity：

Mouse,Rat,(predicted: Human,Dog,Pig,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human hnRNP F

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

46kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
hnRNP F is part of the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). These are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. hnRNP F binds to RNAs which have guanosine-rich sequences.

Function:
Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state.

Subunit:
Identified in the spliceosome C complex. Interacts with AGO1, AGO2, TBP and TXNL4/DIM1.

Subcellular Location:
Nucleus, nucleoplasm.

Tissue Specificity:
Expressed ubiquitously.

Post-translational modifications:
Sumoylated.

Similarity:
Contains 3 RRM (RNA recognition motif) domains.

Database links:

Entrez Gene: 3185 Human

Entrez Gene: 98758 Mouse

Entrez Gene: 64200 Rat

Omim: 601037 Human

SwissProt: Q5E9J1 Cow

SwissProt: P52597 Human

SwissProt: Q9Z2X1 Mouse

SwissProt: Q794E4 Rat

Unigene: 712955 Human

Unigene: 808 Human

Unigene: 422979 Mouse

Unigene: 476420 Mouse

Unigene: 144596 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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