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Rabbit Anti-TBRG1/FITC Conjugated antibody
background:
Acts as a growth inhibitor. Can activate TP53/p53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability. There are two isoforms.
Function:
Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.
Subunit:
Interacts with CDKN2A and MDM2.
Subcellular Location:
Nucleus.
Tissue Specificity:
Widely expressed at low levels in most tissues, with highest levels in pancreas, lung and liver. Expression is decreased in primary tumors including lung, liver, breast, pancreas and kidney carcinomas, chronic lymphocytic leukemia and diffuse large B-cell lymphoma.
Post-translational modifications:
Ubiquitinated; mediated by MDM2 and leading to its subsequent proteasomal degradation.
Similarity:
Belongs to the TBRG1 family.
Contains 1 FYR SLCterminal domain.
Contains 1 FYR N-terminal domain.
Database links:
Entrez Gene: 84897 Human
Entrez Gene: 21376 Mouse
Entrez Gene: 300521 Rat
Omim: 610614 Human
SwissProt: Q3YBR2 Human
SwissProt: Q3UB74 Mouse
SwissProt: Q5PQK8 Rat
Unigene: 436410 Human
Unigene: 28689 Mouse
Unigene: 129282 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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