Rabbit Anti-BNIP3/FITC Conjugated antibody

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BCL2 Adenovirus E1B 19kDa Interacting Protein 3; BCL2/adenovirus E1B 19 kDa protein interacting protein 3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; BNIP 3; BNIP3; BNIP3_HUMAN; NIP 3; NIP3.

Cat:

SL4239R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human BNIP3

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

22kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Apoptosis-inducing protein that, which can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2.

Function:
Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.

Subunit:
Homodimer. Binds to BCL2. Interacts with BNIP3L and ACAA2. Also can interact with adenovirus E1B 19 kDa protein or Epstein-Barr virus SHRF1. Interacts (via SH3 domain) with SPATA18 (via coiled-coil domains).

Subcellular Location:
Mitochondrion. Mitochondrion membrane. Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria.

Similarity:
Belongs to the NIP3 family.

Database links:

Entrez Gene: 664 Human

Entrez Gene: 12176 Mouse

Entrez Gene: 8496 Rat

Omim: 603293 Human

SwissProt: Q12983 Human

SwissProt: O55003 Mouse

Unigene: 144873 Human

Unigene: 378890 Mouse

Unigene: 2060 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

BNIP3蛋白在缺氧条件下可诱导细胞发生细胞凋亡。BNIP3促细胞凋亡线粒体途径根据有无caspase的参与而具有不同的作用机制，也是研究的热点。BNIP3还可诱导细胞自噬。BNIP3全称为Bcl2/腺病毒E1B19kD相互作用蛋白3。(Bcl2/adenovirusE1B19kDainteractingprotein3，BNIP3)，是新近发现的SH3only亚家族成员之一，也是低氧敏感的凋亡基因。在化学性低氧诱导细胞凋亡的过程中，ATP是BNIP3导致细胞凋亡的关键性因素之一。单独ATP下降不诱导细胞凋亡，但ATP下降到一定程度能促进BNIP3向线粒体转位，从而诱导了BNIP3相关的凋亡。这可能是低氧诱导BNIP3表达导致细胞凋亡的重要机制之一。

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