background:
VAPA is a type IV membrane protein, present in the plasma membrane, intracellular vesicles and may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Two transcript variants encoding distinct isoforms have been identified.
Function:
May play a role in vesicle trafficking.
Subunit:
Homodimer, and heterodimer with VAPB. Interacts with VAMP1, VAMP2, STX1A, BET1, SEC22C and with the SLCterminal domain of OCLN. Interacts with OSBPL1A. Interacts (via MSP domain) with ZFYVE27; may retain ZFYVE27 in the endoplasmic reticulum and regulate its function in cell projections formation.
Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Tissue Specificity:
Ubiquitous.
Similarity:
Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. Contains 1 MSP domain.
Database links:
UniProtKB/Swiss-Prot: Q9P0L0.3
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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