background:
Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation.
Function:
Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation.
Subcellular Location:
Secreted, extracellular space, extracellular matrix
Tissue Specificity:
Expressed specifically in the enamel organ.
Post-translational modifications:
Autoactivates at least at the 107-Asn-|-Tyr-108 site
DISEASE:
Defects in MMP20 are the cause of amelogenesis imperfecta hypomaturation type 2A2 (AI2A2) [MIM:612529]. AI2A2 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.
Similarity:
Belongs to the peptidase M10A family.
Contains 4 hemopexin-like domains.
Database links:
UniProtKB/Swiss-Prot: O60882.3
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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