background:
Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a donut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-TP53/p53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of TP53/p53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.
Database links:
Entrez Gene: 420017 Chicken
Entrez Gene: 740582 Chimpanzee
Entrez Gene: 96512 Dog
Entrez Gene: 101131213 Gorilla
Entrez Gene: 10197 Human
Entrez Gene: 19192 Mouse
Entrez Gene: 100171504 Orangutan
Entrez Gene: 397625 Pig
Entrez Gene: 287716 Rat
Entrez Gene: 494719 Xenopus laevis
Entrez Gene: 100124751 Xenopus tropicalis
Omim: 605129 Human
SwissProt: Q5F3J5 Chicken
SwissProt: P61289 Human
SwissProt: P61290 Mouse
SwissProt: Q5RFD3 Orangutan
SwissProt: P61291 Pig
Unigene: 152978 Human
Unigene: 288477 Mouse
Unigene: 198325 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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