Rabbit Anti-GIRK2/FITC Conjugated antibody

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inwardly rectifying subfamily J member 6; Kir3.2; BIR1; G protein activated inward rectifier potassium channel 2; G protein-activated inward rectifier potassium channel 2; GIRK-2; Inward rectifier K(+) channel Kir3.2; IRK6_HUMAN; KATP-2; Kcnj6; Kcnj7; Pot

Cat:

SL4214R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Cow,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human GIRK2

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

47kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Function:
This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Subunit:
Associates with GIRK1 or GIRK4 to form a G-protein-activated heteromultimer pore-forming unit. The resulting inward current is much larger.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Most abundant in cerebellum, and to a lesser degree in islets and exocrine pancreas.

Similarity:
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.

Database links:

Entrez Gene: 3763 Human

Entrez Gene: 16522 Mouse

Entrez Gene: 25743 Rat

Omim: 600877 Human

SwissProt: P9651 Human

SwissProt: P48542 Mouse

SwissProt: P48550 Rat

Unigene: 626242 Human

Unigene: 658533 Human

Unigene: 741904 Human

Unigene: 328720 Mouse

Unigene: 10185 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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