background:
Dehydroepiandrosterone (DHEA) is a major secretory product of the human adrenal cortex during intrauterine development as well as during adulthood. DHEA circulates in the bloodstream as DHEA-sulfate (DHEAS). DHEA has been implicated in a wide range of physiological roles including aging, immunology, learning and memory and obesity.
Function:
Catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands.
Subunit:
Homodimer.
Subcellular Location:
Secreted
Tissue Specificity:
Liver, adrenal and at lower level in the kidney. Is present in human fetus in higher level in the adrenal than the liver and the kidney.
Post-translational modifications:
The N-terminus is blocked.
Similarity:
Belongs to the sulfotransferase 1 family.
Database links:
UniProtKB/Swiss-Prot: Q06520.3
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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