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Rabbit Anti-phospho-TPH (Ser260)/FITC Conjugated antibody
background:
This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009].
Subunit:
Homotetramer (By similarity).
Tissue Specificity:
Isoform 2 seems to be less widely expressed than isoform 1.
Similarity:
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Contains 1 ACT domain.
Database links:
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
色氨酸在脑中首先由色氨酸羟化酶(tryoptophan hydroxylase)催化生成5羟色氨酸(5hydroxytryptophan),再经脱羧酶作用生成5羟色胺,色氨酸羟化酶(TPH)是5-HT生物合成的限速酶,因此,色氨酸羟化酶的缺少可导致5-羟色胺的含量下降。色氨酸羟化酶主要在肝脏内代谢。
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