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Rabbit Anti-phospho-NRP1 (Thr916)/FITC Conjugated antibody
background:
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Function:
The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.
The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
Subunit:
Homodimer, and heterodimer with NRP2. Interacts with FER (By similarity). Binds PLXNB1.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.
Tissue Specificity:
The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.
Similarity:
Belongs to the neuropilin family.
Contains 2 CUB domains.
Contains 2 F5/8 type C domains.
Contains 1 MAM domain.
Database links:
Entrez Gene: 539369 Cow
Entrez Gene: 8829 Human
Omim: 602069 Human
SwissProt: O14786 Human
Unigene: 131704 Human
Unigene: 653996 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CD304是一种神经元受体，被认为表达于众多的非造血细胞上，包括神经元、内皮细胞和肿瘤细胞。在体外单核细胞和造血前体细胞衍生的CD1a+树突状细胞是CD304（BDCA-4/Neuropilin-1）。与CD303(BDCA-2)一样，CD304(BDCA-4)抗原特异性地表达于人血液和骨髓中的浆样树突状细胞。与CD303(BDCA-2)不同的是，CD304(BDCA-4)在培养的浆样树突状细胞上表达上调，同时在培养的髓系细胞能被诱导表达。在感染的扁桃体中，CD304(BDCA-4)不仅表达于浆样树突状细胞，而且在其它细胞上也能检测到，如初级滤泡B辅助性记忆T细胞。
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