background:
The MAP4 (Microtubule associated protein 4)is a non neuronal microtubule associated protein. It promotes microtubule assembly.The phosphorylation of the Pro rich region in the SLCterminus negatively regulates MAP4 activity to promote microtubule assembly.
Function:
Non-neuronal microtubule-associated protein. Promotes microtubule assembly.
Subunit:
Interacts with SEPT2; this interaction impedes tubulin-binding.
Subcellular Location:
Cytoplasm, cytoskeleton.
Post-translational modifications:
Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylation on Ser-787 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 3 is phosphorylated on Ser-337 and Ser-338.
Similarity:
Contains 4 Tau/MAP repeats.
Database links:
UniProtKB/Swiss-Prot: P27816.3
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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