background:
The MAP4 (Microtubule associated protein 4)is a non neuronal microtubule associated protein. It promotes microtubule assembly.The phosphorylation of the Pro rich region in the SLCterminus negatively regulates MAP4 activity to promote microtubule assembly.
Function:
Non-neuronal microtubule-associated protein. Promotes microtubule assembly.
Subunit:
Interacts with SEPT2; this interaction impedes tubulin-binding (By similarity).
Subcellular Location:
Cytoplasm, cytoskeleton.
Tissue Specificity:
Testis, striated and cardiac muscle.
Post-translational modifications:
Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylation on Ser-760 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 4 is phosphorylated on Ser-333 and Ser-334 (By similarity).
Similarity:
Contains 4 Tau/MAP repeats.
Database links:
UniProtKB/Swiss-Prot: P27546.3
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|