Rabbit Anti-phospho-MAP4(Ser941)/FITC Conjugated antibody

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MAP4 (phospho S941); p-MAP4 (phospho S941); MAP4(phospho S941); DKFZp779A1753; MAP-4; MAP4; MAP4_HUMAN; MGC8617; Microtubule associated protein 4; Microtubule-associated protein 4; OTTHUMP00000210723; OTTHUMP00000210725; OTTHUMP00000210727; OTTHUMP0000021

Cat:

SL5438R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,)

Immunogen：

KLH conjugated Synthesised phosphopeptide derived from human MAP4 around the phosphorylation site of Ser941

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

121kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The MAP4 (Microtubule associated protein 4)is a non neuronal microtubule associated protein. It promotes microtubule assembly.The phosphorylation of the Pro rich region in the SLCterminus negatively regulates MAP4 activity to promote microtubule assembly.

Function:
Non-neuronal microtubule-associated protein. Promotes microtubule assembly.

Subunit:
Interacts with SEPT2; this interaction impedes tubulin-binding.

Subcellular Location:
Cytoplasm, cytoskeleton.

Post-translational modifications:
Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylation on Ser-787 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 3 is phosphorylated on Ser-337 and Ser-338.

Similarity:
Contains 4 Tau/MAP repeats.

Database links:
UniProtKB/Swiss-Prot: P27816.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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