Home
>
Product
>
Antibody
>
Rabbit Anti-MAP4/FITC Conjugated antibody
background:
The MAP4 (Microtubule associated protein 4)is a non neuronal microtubule associated protein. It promotes microtubule assembly.The phosphorylation of the Pro rich region in the SLCterminus negatively regulates MAP4 activity to promote microtubule assembly.
Function:
Non-neuronal microtubule-associated protein. Promotes microtubule assembly.
Subunit:
Interacts with SEPT2; this interaction impedes tubulin-binding.
Subcellular Location:
Cytoplasm, cytoskeleton.
Post-translational modifications:
Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylation on Ser-787 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 3 is phosphorylated on Ser-337 and Ser-338.
Similarity:
Contains 4 Tau/MAP repeats.
Database links:
Entrez Gene: 4134 Human
Entrez Gene: 17758 Mouse
Entrez Gene: 367171 Rat
Omim: 157132 Human
SwissProt: P27816 Human
SwissProt: P27546 Mouse
SwissProt: Q5M7W5 Rat
Unigene: 517949 Human
Unigene: 217318 Mouse
Unigene: 443428 Mouse
Unigene: 484451 Mouse
Unigene: 203122 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|