background:
MAX is a basic helix-loop-helix, leucine zipper protein that forms heterodimers with MYC and MAD. It is involved in regulating gene expression.
Function:
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYSLCMAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity.
Subunit:
Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MYC or MAD. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with SPAG9.
Subcellular Location:
Nucleus.
Tissue Specificity:
High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
Post-translational modifications:
Reversible lysine acetylation might regulate the nuclear-cytoplasmic shuttling of specific Max complexes.
Similarity:
Belongs to the MAX family.
Contains 1 bHLH (basic helix-loop-helix) domain.
Database links:
Entrez Gene: 4149 Human
Entrez Gene: 17187 Mouse
Entrez Gene: 60661 Rat
Omim: 154950 Human
SwissProt: P52162 Chicken
SwissProt: P61244 Human
SwissProt: P28574 Mouse
SwissProt: P52164 Rat
Unigene: 285354 Human
Unigene: 4210 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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