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Rabbit Anti-GJB3/FITC Conjugated antibody
background:
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene can cause non-syndromic deafness or erythrokeratodermia variabilis, a skin disorder. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subunit:
A connexon is composed of a hexamer of connexins. Interacts with CNST.
Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
DISEASE:
Defects in GJB3 are a cause of erythrokeratodermia variabilis (EKV) [MIM:13640]. EKV is a genodermatosis characterized by the appearance of two independent skin lesions: transient figurate erythematous patches and hyperkeratosis that is usually localized but occasionally occurs in its generalized form. Clinical presentation varies significantly within a family and from one family to another. Palmoplantar keratoderma is present in around 50% of cases.
Defects in GJB3 are the cause of deafness autosomal dominant type 2B (DFNA2B) [MIM:612644]. DFNA2 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Similarity:
Belongs to the connexin family. Beta-type (group I) subfamily.
Database links:
Entrez Gene: 2707 Human
Entrez Gene: 14620 Mouse
Entrez Gene: 29585 Rat
Omim: 603324 Human
SwissProt: O75712 Human
SwissProt: P28231 Mouse
SwissProt: P25305 Rat
Unigene: 522561 Human
Unigene: 90003 Mouse
Unigene: 162823 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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