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Rabbit Anti-NDV HN protein/FITC Conjugated antibody
background:
The entry of Newcastle disease virus (NDV), a prototype paramyxovirus, is directed by two virion glycoproteins, the hemagglutinin-neuraminidase (HN) protein and the fusion (F) protein . HN protein, the virus attachment protein, binds to sialic acid-containing receptors, and F protein mediates membrane fusion. In contrast to many viral fusion proteins, paramyxovirus F proteins do not require the acid pH of endosomes to activate fusion activity. As a consequence, infected cells expressing both attachment proteins and F proteins can fuse with adjacent cells to form multinuclear cells, or syncytia, a process that is assumed to mimic virus-cell fusion .
Function:
Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins (By similarity).
Subcellular Location:
Virion membrane; Single-pass type II membrane protein (Potential). Host cell membrane; Single-pass type II membrane protein (Potential).
Similarity:
Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.
Database links:
Entrez Gene: 912270 NDV
SwissProt: P32884 NDV
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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