Rabbit Anti-PTOV1/FITC Conjugated antibody

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ACID2; Activator interaction domain containing protein 2; Gcap3; prostate tumor overexpressed 1; Prostate tumor overexpressed gene 1; PTOV 1; PTOV1_HUMAN; Prostate tumor-overexpressed gene 1 protein; PTOV-1; Activator interaction domain-containing protein

Cat:

SL10171R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,)

Immunogen：

KLH conjugated synthetic peptide derived from human PTOV1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

47kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
PTOV1 belongs to the Mediator complex subunit 25 family, PTOV1 subfamily. It may activate transcription and is required for nuclear translocation of FLOT1. PTOV1 promotes cell proliferation. There are three named isoforms.

Function:
PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.

Subunit:
Interacts with PTH1R (via N-terminal extracellular domain).

Subcellular Location:
Secreted.

DISEASE:
Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH) [MIM:146200]; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Similarity:
Belongs to the parathyroid hormone family.

Database links:

Entrez Gene: 53635 Human

Entrez Gene: 84113 Mouse

Entrez Gene: 292888 Rat

Omim: 610195 Human

SwissProt: A4IFC9 Cow

SwissProt: Q86YD1 Human

SwissProt: Q91VU8 Mouse

SwissProt: Q5U2W6 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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