Rabbit Anti-PLCZ1/FITC Conjugated antibody

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1 phosphatidylinositol 4,5 bisphosphate phosphodiesterase zeta 1; Phosphoinositide phospholipase C zeta 1; Phospholipase C zeta 1; PI phospholipase C zeta 1; PLC zeta 1; PLCzeta; Testis development protein NYD SP27; Testis development related NYD SP27; MG

Cat:

SL5378R-FITC

Species Reactivity：

Rat,(predicted: Human,Mouse,Dog,Pig,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human PLCZ1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

70kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, PLCZ1 hydrolyzes PtdIns(4,5)P2 in a Ca2+-dependent manner. It triggers intracellular Ca2+ oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. PLCZ1 is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. It may exert an inhibitory effect on phospholipase-SLCcoupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.

Database links:

Entrez Gene: 89869 Human

Entrez Gene: 114875 Mouse

Entrez Gene: 497197 Rat

Omim: 608075 Human

SwissProt: Q86YW0 Human

SwissProt: Q8K4D7 Mouse

SwissProt: Q5FX52 Rat

Unigene: 97542 Human

Unigene: 50808 Mouse

Unigene: 123184 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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