Home
>
Product
>
Antibody
>
Rabbit Anti-IL-3/FITC Conjugated antibody
background:
The pleiotropic IL3 (Interleukin 3) is a 15kDa cytokine that is primarily secreted by activated T lymphocytes and stimulates the proliferation and differentiation of hematopoietic cells. IL3 acts in hematopoiesis by controlling the production, differentiation, and function of two related white cell populations of the blood, the granulocytes and the monocytes/macrophages. It induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes and is expressed by activated T cells, mast cells, and natural killer cells. IL3 not only supports growth of both pluripotent stem cells and the more differentiated committed progenitors, but it also stimulates the functional activity of some fully differentiated cells. IL3 has also been shown to protect mast cells from undergoing apoptosis.
Function:
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.
This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.
Subunit:
Monomer.
Subcellular Location:
Secreted.
Tissue Specificity:
Activated T-cells, mast cells, natural killer cells.
Similarity:
Belongs to the IL-3 family.
Database links:
Entrez Gene: 3596 Human
Entrez Gene: 16163 Mouse
Entrez Gene: 116553 Rat
Omim: 147683 Human
SwissProt: P35225 Human
SwissProt: P20109 Mouse
SwissProt: P42203 Rat
Unigene: 845 Human
Unigene: 1284 Mouse
Unigene: 9921 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|