background:
ATG4A is a cysteine protease required for autophagy, which cleaves the SLCterminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed SLCterminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.
Function:
Cysteine protease required for autophagy, which cleaves the SLCterminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed SLCterminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP.
Subcellular Location:
Cytoplasm (Probable).
Tissue Specificity:
Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver.
Similarity:
Belongs to the peptidase C54 family.
Database links:
Entrez Gene: 115201 Human
Entrez Gene: 666468 Mouse
Omim: 300663 Human
SwissProt: Q8WYN0 Human
SwissProt: Q8C9S8 Mouse
Unigene: 8763 Human
Unigene: 102230 Mouse
Unigene: 39364 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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