background:
Cysteine protease required for autophagy, which cleaves the SLCterminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed SLCterminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.
Function:
Cysteine protease required for autophagy, which cleaves the SLCterminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed SLCterminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.
Subcellular Location:
Cytoplasm (Probable).
Tissue Specificity:
Highly expressed in skeletal muscle, heart, liver and testis.
Similarity:
Belongs to the peptidase C54 family.
Database links:
Entrez Gene: 84938 Human
Entrez Gene: 242557 Mouse
Entrez Gene: 313391 Rat
Omim: 611339 Human
SwissProt: Q96DT6 Human
SwissProt: Q811C2 Mouse
Unigene: 7353 Human
Unigene: 241663 Mouse
Unigene: 23378 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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