Rabbit Anti-phospho-ASAP1 (Tyr782)/FITC Conjugated antibody

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ASAP1 (phospho-Tyr782); ASAP1 (phospho-Y782); p-ASAP1 (Tyr782); p-ASAP1 (Y782); ASAP1 / DDEF1; AMAP 1; AMAP1; AMAP-1; ARF GTPase activating protein 1; ASAP 1; Centaurin beta 4; CentB4; DDEF 1; DDEF1 protein; PAG 2; PAG2; PAG-2; PAP; PIP2 dependent ARF1 GA

Cat:

SL5176R-FITC

Species Reactivity：

Human,(predicted: Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Guinea Pig,)

Immunogen：

KLH conjugated Synthesised phosphopeptide derived from mouse DDEF1 around the phosphorylation site of Tyr782

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

125kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Function:
Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis.

Subunit:
Homodimer. Interacts with SRC and CRK. Interacts with RAB11FIP3. Interacts with PTK2B/PYK2. Interacts with CTTN. Interacts (via SH3 domain) with APC.

Subcellular Location:
Cytoplasm. Membrane. Note=Predominantly cytoplasmic. Partially membrane-associated

Post-translational modifications:
Phosphorylated on tyrosine residues by SRC

Similarity:
Contains 2 ANK repeats.
Contains 1 Arf-GAP domain.
Contains 1 PH domain.
Contains 1 SH3 domain.

Database links:

Entrez Gene: 50807 Human

Entrez Gene: 327705 Cow

Omim: 605953 Human

SwissProt: O97902 Cow

SwissProt: Q9ULH1 Human

SwissProt: Q9QWY8 Mouse

Unigene: 106015 Human

Unigene: 655552 Human

Unigene: 277236 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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