Rabbit Anti-SLC27A5/FITC Conjugated antibody

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ACSB; ACSVL6; BA CoA ligase; BACS; BAL; Bile acid CoA ligase; Bile acyl CoA synthetase; Cholate CoA ligase; FACVL3; FATP 5; FATP5; Fatty acid Coenzyme A ligase very long chain 3; Fatty acid transport protein 5; Solute carrier family 27 (fatty acid transpo

Cat:

SL4088R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Cow,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human SLC27A5 C-terminus

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

75kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
SLC27A5 is an isozyme of very long chain acyl CoA synthetase (VLCS). It is an acyl CoA synthetase involved in bile acid metabolism and is proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. It seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, it also activates 3 alpha,7 alpha,12 alpha trihydroxy 5 beta cholestanate (THCA), the C27 precursor of cholic acid derived from the de novo synthesis from cholesterol.

Function:
Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.

Subcellular Location:
Endoplasmic reticulum membrane; Multi-pass membrane protein.

Tissue Specificity:
Predominantly expressed in liver.

Similarity:
Belongs to the ATP-dependent AMP-binding enzyme family.

Database links:

Entrez Gene: 10998 Human

Entrez Gene: 26459 Mouse

Omim: 603314 Human

SwissProt: Q9Y2P5 Human

SwissProt: Q4LDG0 Mouse

Unigene: 292177 Human

Unigene: 2204 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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