Rabbit Anti-Cystatin B/FITC Conjugated antibody

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CPI B; CPI-B; CST6; CSTB; Cystatin B; Cystatin-B; CYTB; EPM1; Liver thiol proteinase inhibitor; PME; STFB; CHROW21; CYTB_HUMAN; EPM1A; Stefin-B; ULD.

Cat:

SL5158R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Pig,)

Immunogen：

KLH conjugated synthetic peptide derived from human Cystatin B

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

14kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). [provided by RefSeq, Jul 2008]

Function:
Shows moderate inhibition of cathepsin B but is not active against cathepsin C.

Subcellular Location:
Cytoplasm. Nucleus.Secreted.

Tissue Specificity:
Restricted to the stratum granulosum of normal skin, the stratum granulosum/spinosum of psoriatic skin, and the secretory coils of eccrine sweat glands. Low expression levels are found in the nasal cavity.

Post-translational modifications:
Substrate for transglutaminases. Acts as an acyl acceptor but not as an acyl donor.

Similarity:
Belongs to the cystatin family.

Database links:

Entrez Gene: 1476 Human

Entrez Gene: 13014 Mouse

Entrez Gene: 25308 Rat

Omim: 601145 Human

SwissProt: P04080 Human

SwissProt: Q76LA1 Human

SwissProt: Q62426 Mouse

SwissProt: P01041 Rat

Unigene: 695 Human

Unigene: 6095 Mouse

Unigene: 1233 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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