Rabbit Anti-HuC/FITC Conjugated antibody

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ELAV (embryonic lethal abnormal vision Drosophila) like 3; ELAV-like protein 3 isoform 1; ELAV-like protein 3; Hu antigen C; ELAV like protein 3; ELAVL3; Hu antigen C; HUC; HUCL; Paraneoplastic cerebellar degeneration associated antigen; Paraneoplastic li

Cat:

SL4068R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human ELAVL3/HuC

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

40kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
A member of the ELAVL protein family, ELASLVlike 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq].

Function:
Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance.

Tissue Specificity:
Brain specific.

Similarity:
Belongs to the RRM elav family.
Contains 3 RRM (RNA recognition motif) domains.

Database links:

Entrez Gene: 1995 Human

Entrez Gene: 15571 Mouse

Entrez Gene: 282824 Rat

Omim: 603458 Human

SwissProt: Q14576 Human

SwissProt: Q60900 Mouse

Unigene: 1701 Human

Unigene: 390167 Mouse

Unigene: 22586 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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