Rabbit Anti-Cdc7/FITC Conjugated antibody

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Cdc 7; Cdc-7; Cdc7; CDC7 cell division cycle 7; CDC7 cell division cycle 7 like 1; CDC7 L1; Cdc7 like 1; CDC7 related kinase; CDC7L 1; CDC7L1; Cell division cycle 7 homolog; Cell division cycle 7 kinase; Cell division cycle 7 like protein 1; Cell division

Cat:

SL5148R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human Cdc7

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

Flow-Cyt=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

64kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
DNA replication in eukaryotic cells is dependent on the phosphorylation of the pre-replicative complex (preRC) at the origin of replication. Two complexes of proteins mediate this event, the cyclin dependent kinase (CDK) complex, and the Cdc7 kinase-ASK complex. The activity of Cdc7 kinase oscillates during cell cycle. The major targets of Cdc7 kinase are proteins that belong to the MCM complex (mini chromosome maintenance proteins). Cdc7 kinase was also found to be important in meiosis, checkpoint responses, maintenance of chromosome structure, and repair.

Function:
Seems to phosphorylate critical substrates that regulatethe G1/S phase transition and/or DNA replication. Canphosphorylates MCM2 and MCM3.

Subunit:
Forms a complex with either DSF4/DSF4A or DSF4B, leadingto the activation of the kinase activity.

Subcellular Location:
Nucleus.

Similarity:
elongs to the protein kinase superfamily. Ser/Thrprotein kinase family. CDC7 subfamily.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 8317 Human

Omim: 603311 Human

SwissProt: O00311 Human

Unigene: 533573 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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