Rabbit Anti-Matrin 3/FITC Conjugated antibody

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MATR3; Matrin3; Matrin-3; KIAA0723; Matr3; MATR3_HUMAN; MPD2; VCPDM.

Cat:

SL5141R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human Matrin 3

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

95kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Matrin 3 (MATR 3) is an internal nuclear matrix protein that may play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer MATR 3 may play a role in nuclear retention of defective RNAs. MATR3 forms part of complex consisting of SFPQ, NONO and MATR3. The protein contains 1 matrin type zinc finger and 2 RRM (RNA recognition motif) domains. Two transcript variants encoding the same protein have been identified for this gene.

Function:
May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs.

Subunit:
Part of complex consisting of SFPQ, NONO and MATR3. Interacts with EIF2C1 and EIF2C2.

Subcellular Location:
Nucleus matrix.

DISEASE:
Defects in MATR3 are the cause of myopathy distal type 2 (MPD2) [MIM:606070]; also called vocal cord and pharyngeal dysfunction with distal myopathy (VCPDM). MPD2 is a muscular disorder characterized by distal weakness, with onset in hands and feet, associated with vocal cord and pharyngeal weakness causing a nasal voice and swallowing disorders.

Similarity:
Contains 1 matrin-type zinc finger.
Contains 2 RRM (RNA recognition motif) domains.

Database links:

Entrez Gene: 9782 Human

Entrez Gene: 17184 Mouse

Entrez Gene: 29150 Rat

Omim: 112815 Human

SwissProt: P43243 Human

SwissProt: Q8K310 Mouse

SwissProt: P43244 Rat

Unigene: 268939 Human

Unigene: 595110 Human

Unigene: 215034 Mouse

Unigene: 482118 Mouse

Unigene: 29774 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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