Home > Product > Antibody > Rabbit Anti-Kv4.3/FITC Conjugated antibody
KCND 3; KCND 3L; KCND 3S; KCND3; KCND3L; KCND3S; KSHIVB; Kv 4.3; Potassium ioinic channel Kv4.3; Potassium voltage gated channel Shal related subfamily member 3; Potassium voltage gated channel subfamily D member 3; Sha1 related potassium channel Kv4.3; V
Cat:
SL3762R-FITC
Species Reactivity:
(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,)
Immunogen:
KLH conjugated synthetic peptide derived from human Kv4.3.
Format:
Lyophilized or Liquid
Storage instructions:
bs-2886R
Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration:
1mg/ml
Clonality:
Polyclonal
Isotype:
IgG
Applications:
IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host:
Rabbit
Calculated MW:
73kDa
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Unit:
Price: $
Product PDFs
Datasheet:


background:
Voltage gated potassium (Kv) channels represent the most complex class of voltage gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence related potassium channel genes (shaker, shaw, shab, and shal) have been identified in Drosophila, and each has been shown to have human homologs. This protein is a member of the potassium channel, voltage gated, shal related subfamily, members of which form voltage activated A type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene.

Function:
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.

Subunit:
Homotetramer or heterotetramer with KCND1 and/or KCND2. Interacts with DLG1. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4. Interacts with KCNE1, KCNE2, SCN1B and KCNAB1.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma. Cell projection, dendrite.

Tissue Specificity:
Highly expressed in brain, in particular in the retrosplenial cortex, medial habenula, anterior thalamus, hippocampus, cerebellum and lateral geniculate and superior colliculus. Highly expressed in heart atrium (at protein level) and throughout the ventricle wall, in lung and vas deferens.

Post-translational modifications:
Regulated through phosphorylation at Ser-569 by CaMK2D.

Similarity:
Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily.

Database links:

Entrez Gene: 3752 Human

Entrez Gene: 56543 Mouse

Entrez Gene: 65195 Rat

Omim: 605411 Human

SwissProt: Q9UK17 Human

SwissProt: Q9Z0V1 Mouse

SwissProt: Q62897 Rat

Unigene: 666367 Human

Unigene: 44530 Mouse

Unigene: 10540 Rat

Unigene: 202969 Rat

Unigene: 214215 Rat



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