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Rabbit Anti-eI4EBP2/FITC Conjugated antibody
background:
This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008]
Function:
Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway.
Subunit:
Nonphosphorylated EIF4EBP2 interacts with EIF4E.
Post-translational modifications:
Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF.
Similarity:
Belongs to the eIF4E-binding protein family.
Database links:
Entrez Gene: 1979 Human
Entrez Gene: 13688 Mouse
Entrez Gene: 361845 Rat
Omim: 602224 Human
SwissProt: Q13542 Human
SwissProt: P70445 Mouse
Unigene: 62240 Human
Unigene: 730236 Human
Unigene: 259516 Mouse
Unigene: 24129 Rat
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