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Rabbit Anti-CREM/FITC Conjugated antibody
background:
CREM is a a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is derived from a multiexonic gene that encodes both activators and antagonists of cAMP-inducible transcription by differential splicing. Splice variants with antagonistic function lack 2 glutamine-rich domains and block cAMP-induced transcription, whereas an isoform that includes these glutamine-rich domains is a transcriptional activator.
Function:
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (By similarity).
Subunit:
Binds DNA as a dimer. Interacts with FHL5. Interacts with CDC34.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.
Post-translational modifications:
Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome.
Stimulated by phosphorylation.
Similarity:
Belongs to the bZIP family.
Contains 1 bZIP domain.
Contains 1 KID (kinase-inducible) domain.
Database links:
Entrez Gene: 1390 Human
Entrez Gene: 12916 Mouse
Entrez Gene: 25620 Rat
Omim: 123812 Human
SwissProt: Q03060 Human
SwissProt: P27699 Mouse
SwissProt: Q03061 Rat
Unigene: 200250 Human
Unigene: 5244 Mouse
Unigene: 10251 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CREM是一种与CREB高度同源的蛋白，与CREB均一表达于几种细胞类型不同，其表达具有细胞特异性,CREM同CREB一样能高效特异性结合到CRE元件上，但相反的是其下调cAMP诱导的转录.
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