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Rabbit Anti-CDCA4/FITC Conjugated antibody
background:
CDCA4 is a protein that belongs to the E2F family of transcription factors. This protein regulates E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein pathway. It also functions in the regulaton of JUN oncogene expression. This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1.
Function:
May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity).
Subcellular Location:
Nucleus.
Tissue Specificity:
Highest levels of expression in the pancreas, thymus, testis, spleen, liver, placenta and leukocytes. Relatively low levels in the lung, kidney, prostate, ovary, small intestine and colon. Hardly detectable, if at all, in the brain, skeletal muscle and heart.
Similarity:
Contains 1 SERTA domain.
Database links:
Entrez Gene: 55038 Human
Entrez Gene: 71963 Mouse
Entrez Gene: 500727 Rat
Omim: 612270 Human
SwissProt: Q9BXL8 Human
SwissProt: Q9CWM2 Mouse
Unigene: 34045 Human
Unigene: 313185 Mouse
Unigene: 32426 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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