background:
The enzyme mevalonate pyrophosphate decarboxylase (MVD) catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP.
Function:
Performs the first committed step in the biosynthesis of isoprenes.
Subunit:
Homodimer.
Tissue Specificity:
Expressed in heart, skeletal muscle, lung,liver, brain, pancreas, kidney and placenta.
Similarity:
Belongs to the diphosphomevalonate decarboxylase family.
Database links:
Entrez Gene: 4597 Human
Entrez Gene: 192156 Mouse
Entrez Gene: 81726 Rat
Omim: 603236 Human
SwissProt: Q0P570 Cow
SwissProt: P5722 Human
SwissProt: Q99JF5 Mouse
SwissProt: Q62967 Rat
Unigene: 252457 Human
Unigene: 28146 Mouse
Unigene: 10288 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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