Rabbit Anti-Ceramide synthase 2/FITC Conjugated antibody

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LASS2; TMSG-1; CerS 2; CerS2; L3 antibody LAG1 homolog ceramide synthase 2; LAG1 longevity assurance 2; LAG1 longevity assurance homolog 2; LASS 2; Longevity assurance (LAG1 S. cerevisiae) homolog 2; TMSG 1; TMSG1; Tumor metastasis suppressor; Tumor metas

Cat:

SL5077R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Pig,Cow,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human LASS2

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

45kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
LASS2 (LAG1 homolog, ceramide synthase 2) has sequence similarity to yeast longevity assurance gene 1. It is thought to be involved in sphingolipid synthesis. Expression of LASS2 is transiently increased during the period of active myelination and is specifically localized to white matter tracts of the brain, including the Schwann cells of sciatic nerves suggesting that LASS2 is important for the synthesis of dihydroceramide used for synthesis of myelin sphingolipids. Expression of LASS2 in hepatocellular carcinoma cell lines suppresses the growth of cancer cells.

Function:
Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis.

Subcellular Location:
Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed in kidney, liver, brain, heart, placenta and lung

Similarity:
Contains 1 homeobox DNA-binding domain.
Contains 1 TLC (TRAM/LAG1/CLN8) domain.

Database links:

Entrez Gene: 29956 Human

Entrez Gene: 76893 Mouse

Omim: 606920 Human

SwissProt: Q96G23 Human

SwissProt: Q924Z4 Mouse

Unigene: 713103 Human

Unigene: 741232 Human

Unigene: 181009 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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