background:
DEGS1 is a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. It contains three His containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It has sphingolipid-delta-4-desaturase activity and converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine).
Function:
Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine).
Subcellular Location:
Mitochondrion. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue Specificity:
Ubiquitous.
Post-translational modifications:
Myristoylation can target the enzyme to the mitochondria leading to an increase in ceramide levels.
Similarity:
Belongs to the fatty acid desaturase family. DEGS subfamily.
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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