Rabbit Anti-COL4A3BP/FITC Conjugated antibody

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Alpha 3 type IV collagen binding protein; C43BP_HUMAN; Ceramide transfer protein; Ceramide transporter; CERT; Cert protein; CERTL; col4a3bp; Collagen type IV alpha 3 (Goodpasture antigen) binding protein; Collagen type IV alpha 3 binding protein; Collagen

Cat:

SL5044R-FITC

Species Reactivity：

Rat,(predicted: Human,Mouse,Cow,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human COL4A3BP

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

71kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
COL4A3BP is a kinase that specifically phosphorylates the N terminal region of the non collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Two transcripts exist for this gene.

Function:
Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.

Subunit:
Interacts with COL4A3. Interacts with VAPA and VAPB. Interaction with VAPB is less efficient than with VAPA.

Subcellular Location:
Cytoplasm. Golgi apparatus. Endoplasmic reticulum.

Tissue Specificity:
Widely expressed.

Post-translational modifications:
Phosphorylation on Ser-132 decreases the affinity toward phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity. Inactivated by hyperphosphorylation of serine residues by CSNK1G2/CK1 that triggers dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis.

Similarity:
Contains 1 PH domain.
Contains 1 START domain.

Database links:

Entrez Gene: 10087 Human

Entrez Gene: 13618 Mouse

Entrez Gene: 365652 Rat

Omim: 604677 Human

SwissProt: Q9GKI7 Cow

SwissProt: Q9Y5P4 Human

SwissProt: Q9EQG9 Mouse

Unigene: 270437 Human

Unigene: 24125 Mouse

Unigene: 105704 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

COL4A3BP蛋白目前，主要用于Goodpasture综合征等方面的研究。

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