background:
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A Thioesterase 8, also known as ACOT8 may mediate Nef-induced down-regulation of CD4. It is a major thioesterase in peroxisomes and competes with BAAT (Bile acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). It shows a preference for medium-length fatty acyl-CoAs and may be involved in the metabolic regulation of peroxisome proliferation.
Function:
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (By similarity). May be involved in the metabolic regulation of peroxisome proliferation.
Subunit:
Interacts with HISLV1 Nef.
Subcellular Location:
Peroxisome.
Tissue Specificity:
Detected in a T-cell line (at protein level). Ubiquitous.
Similarity:
Belongs to the C/M/P thioester hydrolase family.
Database links:
Entrez Gene: 10005 Human
Entrez Gene: 170789 Mouse
Entrez Gene: 170588 Rat
GenBank: NM_005469.3 Human
Omim: 608123 Human
SwissProt: O14734 Human
SwissProt: P58137 Mouse
SwissProt: Q8VHK0 Rat
Unigene: 444776 Human
Unigene: 277878 Mouse
Unigene: 161868 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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