background:
Hepatitis B Virus (HBV) infection induces a disease state characterised by liver damage, inflammation and viral persistence. Infection also increases the risk of hepatocellular carcinoma. HBV belongs to the Hepadnaviridae family of viruses. Its genome consists of partially double stranded circular DNA. The DNA is enclosed in a nucleocapsid, or core antigen (HBcAg), which is surrounded by a spherical envelope (surface antigen or HBsAg). The core antigen shares its sequences with the e antigen (HBeAg) but no cross reactivity between the two proteins has been observed. The HBV genome also encodes a DNA polymerase that also acts as a reverse transcriptase. Hepatitis B infection is normally diagnosed from serological tests that detect HBsAg but as the disease progresses this antigen may no longer be present in the blood and tests for HBcAg are used. If HBsAg can be detected in the blood for longer than six months, chronic hepatitis B is diagnosed. The antigenic determinant of the protein moiety of the HBsAg determines specific characteristics of different serotypes and provides the basis of immunodetection. HBsAg has antigenic heterogeneity, specifically, two pairs of sub specific determinants, d/y and w/r allow the following combinations: adw, ayw, adr, ayr.
Function:
Li-HBsAg interacts with capsid protein and with HDV Large delta antigen. Isoform M associates with host chaperone CANX through its pre-S2 N glycan. This association may be essential for M proper secretion.
Subunit:
Li-HBsAg interacts with capsid protein and with HDV Large delta antigen. Isoform M associates with host chaperone CANX through its pre-S2 N glycan. This association may be essential for M proper secretion.
Subcellular Location:
Virion membrane.
Post-translational modifications:
Isoform M is N-terminaly acetylated at a ratio of 90%, and N-glycosylated at the pre-S2 region.
Myristoylated.
Similarity:
Belongs to the orthohepadnavirus major surface antigen family.
Database links:
Entrez Gene: 2703546 Hepatitis B virus
SwissProt: P03142 Hepatitis B virus
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
乙型肝肝炎病毒颗粒直径42nm，由包膜与核衣壳组成，包膜含有碳水化合物、蛋白质和脂类。其中蛋白质为主要抗原成分，包括S抗原：pre-s1区和pre-s2区，这些抗原成分在病毒侵入细胞过程中有着至关重要的作用，为深入研究乙型肝肝炎病毒发病机理及变异有着至关重要的作用。
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