background:
ALDOB is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Defects in ALDOB cause hereditary fructose intolerance.
Subunit:
Homotetramer.
DISEASE:
Hereditary fructose intolerance (HFI) [MIM:229600]: Autosomal recessive disease that results in an inability to metabolize fructose and related sugars. Complete exclusion of fructose results in dramatic recovery; however, if not treated properly, HFI subjects suffer episodes of hypoglycemia, general ill condition, and risk of death the remainder of life. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:
Belongs to the class I fructose-bisphosphate aldolase family.
Database links:
Entrez Gene: 229 Human
Entrez Gene: 230163 Mouse
Entrez Gene: 24190 Rat
Omim: 612724 Human
SwissProt: P05062 Human
SwissProt: Q91Y97 Mouse
SwissProt: P00884 Rat
Unigene: 530274 Human
Unigene: 482116 Mouse
Unigene: 98207 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
醛缩酶（ALD）与机体能量代谢密切相关。醛缩酶含量比较丰富，分布也叫广泛，醛缩酶B是一种与糖酵解有关的酶类，在人类和哺乳动物组织中存在3种醛缩酶同工酶，即A(肌型)，B(肝型)和C（脑型）。其中B型基因定位于q13-q32，属胞浆酶。研究表明，ALDOB在肝细胞癌发展过程中呈现出一定规律的变化，与原发性肝癌有关。ALDOB蛋白主要定位于胞浆。
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