Home
>
Product
>
Antibody
>
Rabbit Anti-Hexokinase 1/FITC Conjugated antibody
background:
The hexokinases utilize Mg-ATP as a phosphoryl donor to catalyze the first step of intracellular glucose metabolism, the conversion of glucose to glucose-6-phosphate. Four hexokinase isoenzymes have been identified, including hexokinase I (HXK I), hexokinase II (HXK II), hexokinase III (HXK III) and hexokinase IV (HXK IV, also designated glucokinase or GCK). Hexokinases I-III each contain an N-terminal cluster of hydrophobic amino acids. Glucokinase lacks the N-terminal hydrophobic cluster. The hydrophobic cluster is thought to be necessary for membrane binding. This is substantiated by the finding that glucokinase has lower affinity for glucose than do the other hexokinases. HXK I has been shown to be expressed in brain, kidney and heart tissues as well as in hepatoma cell lines. HXK II is involved in the uptake and utilization of glucose by adipose and skeletal tissues. Of the hexokinases, HXK III has the highest affinity for glucose. Glucokinase is expressed in pancreatic beta cells where it functions as a glucose sensor, determining the “set point” for insulin secretion.
Subunit:
Monomer.
Subcellular Location:
Mitochondrion outer membrane. Note=Its hydrophobic N-terminal sequence may be involved in membrane binding.
Tissue Specificity:
Isoform 2 is erythrocyte specific. Isoform 3 and isoform 4 are testis-specific.
DISEASE:
Defects in HK1 are the cause of hexokinase deficiency (HK deficiency) [MIM:235700]. HK deficiency is a rare autosomal recessive disease with nonspherocytic hemolytic anemia as the predominant clinical feature.
Similarity:
Belongs to the hexokinase family.
Database links:
Entrez Gene: 3098 Human
Entrez Gene: 15275 Mouse
Entrez Gene: 25058 Rat
Omim: 142600 Human
SwissProt: P19367 Human
SwissProt: P17710 Mouse
SwissProt: P05708 Rat
Unigene: 370365 Human
Unigene: 196605 Mouse
Unigene: 11017 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|